Research-grade to GMP manufacturing. Solid-phase synthesis, modifications, purification, and full analytical characterization. A Patient Analog resource for peptide development.
Standard service offerings available from peptide contract research organizations.
Solid-phase peptide synthesis (SPPS) using Fmoc or Boc chemistry. Linear and cyclic peptides from 5 to 100+ amino acids. Standard and non-natural amino acid incorporation.
N-terminal acetylation, C-terminal amidation, PEGylation, lipidation, fluorescent labeling, biotinylation, and disulfide bridge formation.
Preparative HPLC purification to >95%, >98%, or >99% purity. Multiple purification runs for difficult sequences. Lyophilization and custom formulation.
LC-MS, MALDI-TOF, amino acid analysis, peptide mapping, sequence confirmation, and certificate of analysis for each batch.
Process development for larger batches. Tech transfer to GMP facilities. IND-enabling manufacturing with full documentation.
ICH-compliant stability testing. Accelerated and real-time conditions. Degradation pathway analysis and shelf-life determination.
Typical scale ranges and applications for peptide synthesis projects.
| Scale | Quantity Range | Typical Use | Grade | Timeline |
|---|---|---|---|---|
| Discovery | 1-10 mg | Initial screening, assay development | Research | 1-2 weeks |
| SAR Studies | 10-100 mg | Structure-activity relationship, lead optimization | Research | 2-3 weeks |
| In Vivo Studies | 100 mg - 1 g | Animal PK/PD, efficacy studies | Pilot | 3-4 weeks |
| Tox Studies | 1-10 g | GLP toxicology, safety assessment | Pilot | 4-6 weeks |
| Clinical Supply | 10-100 g | Phase I/II clinical trials | GMP | 8-12 weeks |
| Commercial | 100 g - kg | Phase III and commercial manufacturing | GMP | Project-specific |
Timelines are estimates and vary based on sequence complexity, modifications, and purity requirements.
Chemical modifications to enhance peptide stability, activity, or detection.
Standard techniques used to confirm peptide identity, purity, and quality.
ESI-MS, MALDI-TOF for molecular weight confirmation and impurity identification
RP-HPLC for purity assessment, typically C18 column with UV detection at 214/280 nm
Quantitative composition analysis, content determination for formulation
Edman degradation or MS/MS fragmentation for sequence verification
Orthogonal purity method, charge variant analysis
Secondary structure characterization, conformational analysis
Standard workflow from sequence submission to final delivery.